Metal Complexes of Heterocyclic Hydrazone Schiff-bases; Preparation, Spectral Characterisation and Biological Study

Articles in Press

Document Type : Regular Paper

Authors

1 Department of Chemistry University of Baghdad

2 College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad

3 College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad,

4 College of Science, University of Al-Anbar

Abstract

New isatinic hydrazone Schiff-base ligands namely; furan-2-carboxylic acid (2-oxo-1,2-dihydro-indol-3-ylidene)-hydrazide) (L1), thiophene-2-carboxylic acid (2-oxo-1,2-dihydro-indol-3-ylidene)-hydrazide (L2) and 2-(pyridine-2-yl-hydrazono)-1,2-dihydro-indol-3-one) (L3) are reported. The ligands were prepared by the condensation of furan-2-carboxylic acid hydrazide (L1), thiophene-2-carboxylic acid hydrazide (L2), and 2-hydrazino pyridine (L3) with isatine. Monomeric complexes were prepared from the reaction of the corresponding metal chloride with the ligands. The ligands and their nine new complexes of the general formulae [M(Ln)2]Cl2 (where M= Co(II), Zn(II) and Cd(II); n= L1, L2 and L3), were characterised by spectroscopic methods (FTIR, UV-Vis, 1H, 13C NMR), elemental analysis, metal content, magnetic measurement and molar conductance. These studies revealed the formation of six coordinate complexes, in which the geometry about metal atom is a distorted octahedral. Biological activity of the ligands and their metal complexes against gram positive bacterial strain Bacillus (G+) and gram negative bacteria Ecoli (G-) are evaluated. The effects of prepared compounds depend on the type of tested bacteria. It is clear that, the ligands and their metal complexes have a potential effect on the gram positive (G+) and gram negative (G-) strains of the tested bacteria.

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Iranian Journal of Science

Articles in Press, Accepted Manuscript
Available Online from 15 November 2015

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