The influence of administration of different dose of arginine and lysine coupled with cadmium in the lactating ewes on the cadmium concentration in milk

Document Type : Regular Paper


1 Shahid Beheshti University

2 Applied Scientific Education Institute of Jahad Keshavarzi


Cadmium (Cd) is a toxic heavy element. Increases in Cd level might cause many disorder, so it is important to controlling amount of this heavy metal in both animals and humans. In mammary gland the mechanism of Cd uptake is not quite clear. The purpose of this study was to determine whether Cd can pass through the mammary epithelial cell into milk by co-transport system with amino acid in the lactating ewes. This experimental research included 54 lactating ewes which collected from Department of State Organization Agriculture of Tehran province, were allocated into 9 groups as follow: groups which received inorganic form as cadmium chloride (1, 2 and 4 mg kg-1 of B.W.), and groups which received organic Cd with different dose of arginine or lysine (1, 2 and 4 mg kg-1 of B.W.) in chelate form. Milk sample were taken 30 min before and 6 hours after intravenous injection of Cd preparations. Cd concentration in milk was measured using the flame atomic absorption spectrometric method. There are no significant difference between groups in milk’s Cd concentration before administration of inorganic or organic Cd. Data analysis showed that administration of inorganic Cd caused a significant increase of Cd concentration in the milk (p


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