Hexamethylenetetramine as an efficient and reusable organocatalyst in Henry reaction under mild and aqueous solution

Document Type : Regular Paper

Authors

Chemistry Department, College of Sciences, Shiraz University

Abstract

Henry reaction is a base catalyzed reaction which can produce β-nitroalcohol or nitroethylene derivatives from the condensation of aryl aldehydes and nitromethane under different conditions. In the present article, we introduce hexamethylenetetramine as a basic organocatalyst for Henry reaction, which can produce β-nitroalcohol derivatives from the condensation of aryl aldehydes and nitromethane under different conditions. By application of this organic base, β-nitroalcohol ompounds were produced as the only product in good to excellent yields. Also reusability of hexamethylenetetramine in this reaction makes our method green.

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