ZnO mediated a cheap, efficient, and mild synthesis of unsymmetrical carboxylic acid anhydrides

Document Type: Regular Paper


Department of Chemistry, College of Sciences, Shiraz University, Shiraz, Iran


The treatment equimolar quantities of carboxylic acids with acid chlorides in the presence of ZnO brings about
highly efficient unsymmetrical anhydrides at room temperature in solvent-free condition. Reactivity trends
favored formation of the product using both electron deficient and rich aryl acids and acid chlorides.