TY - JOUR ID - 2225 TI - HYPOLIPIDAEMIC EFFECT OF ACANTHOPHORA SPICIFERA (RED ALGA) AND CYSTOSEIRA TRINODE (BROWN ALGA) ON ALBINO RATS JO - Iranian Journal of Science JA - ISTT LA - en SN - 2731-8095 AU - HETTA, M. AU - HASSAN, S. AU - ABDEL-TAWAB, S. AU - BASTAWY, M. AU - MAHMOUD, B. AD - Pharmacognosy Department, Faculty of Pharmacy, Beni Suef Univ., Egypt AD - Botany Department, Faculty of Science, Beni Suef Univ., Egypt AD - Zoology Department, Faculty of Science, Beni Suef Univ., Egypt AD - Chemistry Department, Faculty of Science, Beni Suef Univ., Egypt AD - Biochemistry Department, Faculty of Science, Beni Suef Univ., Egypt Y1 - 2009 PY - 2009 VL - 33 IS - 4 SP - 287 EP - 297 KW - Acanthophora spicifera KW - Cystoseira trinode KW - sulfated polysaccharides KW - hypolipidaemic KW - Histopathology KW - biochemical parameters DO - 10.22099/ijsts.2009.2225 N2 - The polysaccharides of Acanthophora spicifera and Cystoseira trinode were isolated and theircomponents identified using different chemical and spectral techniques. Their effects were evaluated for thefirst time on hyperlipidemic rats. Atorvastatin Ca (Lipitor®) was used as a reference drug. Results revealedthat the polysaccharides isolated were of sulfate type. Acanthophora spicifera lowered the level of total serumlipids, total cholesterol (TC), triglycerides (TG) and low-density lipoproteins (LDL-C) by 48%, 49.6%, 63%and 80.6% respectively. High-density lipoproteins (HDL-C) level was elevated by 1.14 fold. For Cystoseiratrinode total lipids, TC, TG and LDL-C were decreased by 25.5%, 49%, 51% and 91% respectively. The levelof HDL-C was elevated by 1.5 fold in comparison with the hyperlipidemic rats. The histopathological resultsproved the ameliorated effect after using the isolated polysaccharides of both algae. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were decreased in hypercholesterolemic groups by values of 63%, 34% and 45%, respectively when treated with A. spicifera extract. The treatment with C. trinode extract and Atorvastatin exhibited a noticeable amelioration in activity with hypercholesterolemic groups as compared to their corresponding controls. UR - https://ijsts.shirazu.ac.ir/article_2225.html L1 - https://ijsts.shirazu.ac.ir/article_2225_3bd0acf918ac02c1c7b8fb0eb15db6e8.pdf ER -